Reading literature with the aid of computational techniques is controversial. For some, digital approaches apparently fetishize the curation of textual archives, lack interpretative rigor, and are thoroughly ’neoliberal’ in their pursuit of Silicon Valley-esque software-tool production. For others, the potential benefits of amplifying reading-labor-power through non-consumptive use of book corpora fulfills the dreams of early twentieth-century Russian formalism and yields new, distant ways in which we can consider textual pattern-making (Jockers; Moretti, Distant Reading; Moretti...

Pharmacogenetics is an emerging biotechnology concerned with understanding the genetic basis of drug response, and promises to transform the development, marketing and prescription of medicines. This paper is concerned with analysing the move towards segmented drug markets, which is implicit in the commercial development of pharmacogenetics. It is claimed that in future who gets a particular drug will be determined by their genetic make up. Drawing on ideas from the sociology of expectations we examine how pharmaceutical and biotechnology companies are (...) constructing, responding to and realising particular ‘visions’ or expectations of pharmacogenetics and market stratification. We argue that the process of market segmentation remains uncertain, but that the outcome will be fashioned according to the convergence and divergence of the interests of key commercial actors. Qualitative data based both on interviews with industry executives and company documentation will be used to explore how different groups of companies are developing pharmacogenetics in distinct ways, and what consequences these different pathways might have for both clinical practice and health policy. In particular, the analysis will show a convergence of interests between biotechnology and pharmaceutical companies for creating segmented markets for new drugs, but a divergence of interest in segmenting established markets. Whilst biotechnology firms have a strong incentive to innovate, the pharmaceutical industry has no commercial interest in segmenting markets for existing products. This has important implications, as many of the claimed public health benefits of pharmacogenetics will derive from changing the prescribing of existing medicines. One significant implication of this is that biotechnology companies who wish to apply pharmacogenetics to existing medicines will have to explore an alternative convergence of interests with healthcare payers and providers . Healthcare providers may have a strong incentive to use pharmacogenetics to make the prescribing of existing medicine more cost-effective. However, we conclude by suggesting that a question mark hangs over their ability to provide the necessary economic and structural resources to bring such a vision to fruition. (shrink)

Ethical internalism is a view that links an agent's reasons to be moral with his or her motivation to be moral. At least two kinds of ethical internalism can be distinguished. "Socratic" ethical internalism is the view that an agent cannot think he has a moral reason to perform some action unless he has some motivation so to act. "Humean" ethical internalism is the view that moral reasons give genuine reasons for acting only when the action serves one of the (...) agent's desires or other "motivating" attitudes. I argue that neither Socractic nor Humean internalism is defensible. ;The central difficulty with Socratic internalism is that, if it can be tested at all, it involves the ascription of a desire, on the part of all competent agents, not to act immorally. But I argue that this "desire thesis" is itself unverifiable, so that the Socratic internalist thesis cannot be tested. These criticisms are applied to the views of R. M. Hare, H. A. Prichard, and Thomas Nagel. ;On the other hand, the Humean internalist, I argue, generally overstates the ability of agents to perceive and evaluate their own reasons for acting. This leads the Humean internalist wrongly to downplay the role of an agent's interests in determining his or her reasons for acting. I show how the views of the Humean internalist conflict with common-sense views about the ascription of reasons for acting, and apply the criticisms to the works of Philippa Foot, Bernard Williams, and Gilbert Harman. ;Finally, I develop an "externalist" account of reasons for acting. According of this account, the reasons properly ascribable to an agent do not depend in any essential way on the motivating attitudes that are ascribed to an agent. I argue that the externalist account best accords with our intuitions about the ascription of reasons for acting. And I conclude by examining the possibility of using the externalist account of reasons to justify the imposition of legal liability on agents. (shrink)

Digital spaces are saturated with metaphor: we have pages, sites, mice, and windows. Yet, in the world of digital textuality, these metaphors no longer function as we might expect. Martin Paul Eve calls attention to the digital-textual metaphors that condition our experience of digital space, and traces their history as they interact with physical cultures. Eve posits that digital-textual metaphors move through three life phases. Initially they are descriptive. Then they encounter a moment of fracture or rupture. Finally, (...) they go on to have a prescriptive life of their own that conditions future possibilities for our text environments - even when the metaphors have become untethered from their original intent. Why is "whitespace" white? Was the digital page always a foregone conclusion? Over a series of theses, Eve addresses these and other questions in order to understand the moments when digital-textual metaphors break and to show us how it is that our textual softwares become locked into paradigms that no longer make sense. Contributing to book history, literary studies, new media studies, and material textual studies, Theses on the Metaphors of Digital-Textual History provides generative insights into the metaphors that define our digital worlds. (shrink)

What is there not to like about “openness”? The premise seems to have virtue, particularly in the space of critique of government. From totalitarianism through to oligarchies, it can be argued that it is opacity and secrecy that have contributed to abuses of power for many centuries. In other spaces, the notion has caught hold. In several scientific fields, it appears that a lack of openness can lead to misconduct and in some cases a slowness that may cost lives. In (...) the humanities, we might say that its absence fosters insularity. In computer software production, open-source paradigms have led to remarkable developments such as the Linux kernel and allowed us to see the inner machinations of the code that is.. (shrink)

Two major reports in the UK and USA have recently sanctioned as ethically acceptable genome editing of future generations for the treatment of serious rare inherited conditions. This marks an important turning point in the application of recombinant DNA techniques to humans. The central question this paper addresses is how did it became possible for human genetic engineering (HGE) of future generations to move from an illegitimate idea associated with eugenics in the 1980s to a concrete proposal sanctioned by scientists (...) and bioethicists in 2020? The paper uses the concept of a regime of normativity to understand the co-evolution and mutual shaping of technology, imaginaries, norms and governance processes in debates about HGE in the USA and UK. It will be argued that interlinked discursive, institutional, political and technological changes have made proposals for the use of genome editing in the genetic engineering of future generations both “thinkable” and legitimate. (shrink)

Genome editing enables very accurate alterations to DNA. It promises profound and potentially disruptive changes in healthcare, agriculture, industry, and the environment. This paper presents a multidisciplinary analysis of the contemporary development of genome editing and the tension between continuity and change. It draws on the idea that actors involved in innovation are guided by “sociotechnical regimes” composed of practices, institutions, norms, and cultural beliefs. The analysis focuses on how genome editing is emerging in different domains and whether this marks (...) continuity or disruption of the established biotechnology regime. In conclusion, it will be argued that genome editing is best understood as a technology platform that is being powerfully shaped by this existing regime but is starting to disrupt the governance of biotechnology. In the longer term is it set to converge with other powerful technology platforms, which together will fundamentally transform the capacity to engineer life. (shrink)

ABSTRACT A key selling point of pharmacogenetics is the genetic stratification of either patients or diseases in order to target the prescribing of medicine. The hope is that genetically ‘tailored’ medicines will replace the current ‘one‐size‐fits‐all’ paradigm of drug development and usage. This paper is concerned with the relationship between difference and justice in the use of pharmacogenetics. This new technology, which facilitates the identification and use of difference, has, we shall argue, the potential to lead to injustice either by (...) the inappropriate use of difference or through the inappropriate failure to use difference. We build on empirical data from a detailed study of the range of options for the development of pharmacogenetics to present a consideration of the ethical issues that surround patient and disease stratification. In it we explore the ways in which the use of pharmacogenetics may lead to the creation of new, genetically stratified, forms of difference and new forms of injustice based on these divisions. We also examine the ways in which existing forms of difference and social stratification may interact with the use of pharmacogenetics. In conclusion, we suggest how an understanding of these ethical issues could usefully inform future policy discussions. (shrink)

This paper explores the way in which God as the infinite ground of existence is discerned by the imagination and understanding. The representation of the apophatic divine is facilitated by the working of the human mind, which means that the manifold nature of thinking establishes the presence of God. In the metaphysical speculations of kabbalah and tantra the singular light of Ein Sof and Paramashiva intersects with the human imagination, and is refracted into a multiple display of understanding. So the (...) mind acts as a prism through which God is conceptualized and delineated. It constitutes a mediated envisaging of the Absolute, and the corollary of this perception is the engendering of the divine presence, notably as the feminine Shekhinah and Shakti. In short, in these two apparently different traditions—of kabbalistic and tantric thought—there is a detectably common theme of the notions of activity and force in creation as betokening a feminine representation of God’s being. (shrink)

Academic health centres have historically treated patients with the most complex of diseases, served as training grounds to teach the next generations of physicians and fostered an innovative environment for research and discovery. The physicians who hold faculty positions at these institutions have long understood how these key academic goals are critical to serve their patient community effectively. Recent healthcare reforms, however, have led many academic health centres to recruit physicians without these same academic expectations and to partner with non-faculty (...) physicians at other health systems. There has been limited transparency in regard to the expertise among the physicians and the academic faculty within these larger entities. Such lack of transparency may lead to confusion among patients regarding the qualifications of who is actually treating them. This could threaten the ethical principles of patient autonomy, benevolence and non-maleficence as patients risk making uninformed decisions that might lead to poorer outcomes. Furthermore, this lack of transparency unjustly devalues the achievements of physician faculty members as well as potentially the university they represent. In this paper, it is suggested that academic health centres have an obligation to foster total transparency regarding what if any role a physician has at a university or medical school when university or other academic monikers are used at a hospital. (shrink)

This work is an attempt to explore both the increase in and the breadth of popular collecting in Britain. It does this by examining the contexts of social change over the past 20 years. This change, it is argued, has led to a culture of social and material insecurity, in which collecting is used for the creating and defence of identity. The social theory of Guy Debord is employed as an underlying philosophy in which contemporary popular collecting is interpreted as (...) an expression of a moral value system in a society driven by market forces. The social world and values of collectors are explored through their clubs. These, it is asserted, comprise an alternative society, one in which a legitimization of the collector's activities and preferences can be made and in which they develop a complementary reality. (shrink)

In this paper I shall argue that useful correspondences can be drawn between the role of depiction in showing a view of the world and the realisation that would view God as a picture of experience in the world, since both can be seen to illustrate an art of interpretation. The perceptual insight that is gleaned in mystical-philosophical consciousness converges on the idea of a realm that is marked as divine, and by exploiting mental and linguistic imagery this mindful awareness (...) can be made concrete in the form of a written text, which can be seen to be analogous to a pictorial representation. The writer of a text purportedly sees and knows the domain of divine reality through sensible and conceptual means and then reduces this consciousness to a planar form, which is observable as an artistic rendering. The reader, who is at the same time a viewer, is invited to perceptually and imaginatively attend to the artifact as a manifestation of the experient's understanding of the functional nature of God, and in this apprehension of the divine scenario in the textual picture the interpretative motif of God-in-the-painting is revealed. (shrink)

This paper examines the relation of body, soul, and God in the context of spiritual desire. It connotes a gendered relationship with the nature of divinity. A prime exponent of this mode of realization is Mechthild of Magdeburg, who longingly reaches for God, and employs vivid imagery in describing her quest.

There has been a longstanding interest in discovering or uncovering resemblances among what are ostensibly diverse religious schemas by employing a range of methodological approaches and tools. However, it is generally considered a problematic undertaking. Jonathan Z. Smith has produced a large body of work aimed at explicating this and has tacitly based his model of comparison on metaphor, which is traditionally understood to connote similarity between two or more things, as based on a linguistic or pragmatic assessment. However, another (...) possible approach is cognitive. George Lakoff and Mark Johnson have championed the view of “conceptual metaphor,” which regards metaphor as being pervasive not only in language, but also in thought and action. Indeed, according to them, it basically structures our conceptual operations and hence views of the world through partially mapping knowledge across ontological domains, generally from the concrete to the abstract. I shall argue that a similar mechanism can fruitfully be applied to comparing religious schemas, as based on the postulated relationship between the domains of human and divine, physical and abstract, and as realized through expressions of journeying and reflection. (shrink)

In this paper I consider the way in which divinity is realized through an imaginary locus in the mystical thought of Jewish kabbalah and Hindu tantra. It demonstrates a reflective consciousness by the adept or master in understanding the place of God’s being, as a supernal and mundane reality. For the comparative assessment of these two distinctive approaches I shall use as a point of departure the interpretative strategies employed by Elliot Wolfson in his detailed work on Jewish mysticism. He (...) argues that there is an androcentric bias embedded in the speculative outlook of medieval kabbalah, as he reads the texts through a psychoanalytic lens. In a similar way, I will argue that there is an androcentric bias to the speculations presented in medieval Shaiva tantra, in particular that division known as the Trika. Overall, my aim is to suggest some functional and perhaps structural similarities to the characterization of divinity in these two traditions, through brief analyses of the erotic understanding of the nature of the Godhead. (shrink)

What does it mean to talk of the power of God in relation to the human self? The discourses generated by the Jewish and Christian tradition about the capacity for divinity have been mainly promulgated by men, and have more often than not served to exclude women cognitively, practically, and spiritually. As a result they have been made powerless in the face of God’s presence. It is possible to look to ideas developed in Hindu Tantra for comparative notions of power (...) (shakti) which can redeem the place of God for women. The path of divine consciousness is effectively illustrated by an imaginary and somatic awareness, by a devout attention to the play of light in the soul. In this paper I propose to read the assignment of energy and force within conceptions of divinity through the lens of a poststructuralist realization, using the work of Michel Foucault, Gilles Deleuze and Félix Guattari, and Luce Irigaray. This working paper is basically an exercise in metaphorical writing, and one reader has called it 'creative theology'. (shrink)

In this paper I consider the apparently distinctive outlooks indicated by the mystical thought of Jewish kabbalah and Hindu tantra as they aim at realizing the scope of divine awareness. It is a profound horizon of light that beckons to them, which shows them to be on the verge of touching God. For both traditions there is a demonstrative reflective consciousness by the practitioner in realizing and recognizing the place of God’s being, as a supernal and mundane reality. It is (...) an attempt to grasp that which is otherwise unreachable and unknowable, by pointing to a sublimely felt reality. I argue that there are some phenomenological similarities to the way in which approaching the divine is understood in these two systems, especially in regard to the role of specularity in apprehending and discriminating the place of God. (shrink)

Since its emergence as an academic discipline in the early 1970s, feminist commentary and scholarship has prosecuted a critique of androcentric or sexist (gender exclusive) language, which has to some extent been successful. The struggle by women to occupy a positive linguistic space is continually being challenged by the endemic nature of masculine bias, which is realized through “indirect” or “subtle” sexism in the community. Seemingly innocuous words, like guy/guys, are frequently used to represent both men and women, reminiscent of (...) the previous use of man/men as gender inclusive common nouns. This raises the question of how to account for the persistence of such language use in spite of the fact that attention is regularly drawn to its problematic character. In this paper we approach the matter in a novel way, by appealing to work in the field of cognitive semantics, in particular the conceptual theory of metonymy. We propose that the relationship between the concepts of masculine and feminine as these are typically structured through language is indicative of a metonymy THE MASCULINE FOR THE FEMININE, in which the masculine “stands for” the feminine and in which lexical items are given as inclusive yet in effect refer to one (normative) gender. A corollary is that the feminine is subsumed (really or virtually) by the presence of the masculine and is made to disappear, and only reappears when she needs to be specified within the contextual frame. (shrink)

The ongoing debate about the FDA approval of BiDil in 2005 demonstrates how the first racially/ethnically licensed drug is entangled in both Utopian and dystopian future visions about the continued saliency of race/ethnicity in science and medicine. Drawing on the sociology of expectations, this paper analyzes how scientists in the field of pharmacogenetics are constructing certain visions of the future with respect to the use of social categories of race/ethnicity and the impact of high-throughput genotyping technologies that promise to transform (...) scientific practices. (shrink)

In a recent discussion about how scientific knowledge might potentially change our understanding of the nature and extent of human genetic, cultural, or biological variation, the sociologist David Skinner identified two competing visions of the future: one that was decidedly dystopian, which conjured up a “re-racialized” future, and an opposing utopian future in which the potential for racialized thinking might be finally overcome. We can situate the ongoing debates about the congestive heart failure drug BiDil, approved by the Food and (...) Drug Administration for use only by African Americans, in relation to these differing future prospects.When the FDA announced its approval of BiDil in June 2005, it located the drug, and perhaps the future of pharmaceutical development, within a particular vision of the future, heralding BiDil as “representing a step toward the promise of personalized medicine.” The discourse of “personalized medicine” can be characterized as part of a utopian future, one in which clinicians will be able to make increasingly individualized decisions based on each patient’s genetic makeup so that the drugs they take will be those that work best for them. (shrink)

"Evidence of a flight from reason is as old as human record-keeping: the fact of it certainly goes back an even longer way. Flight from science specifically, among the forms of rational inquiry, goes back as far as science itself... But rejection of reason is now a pattern to be found in most branches of scholarship and in all the learned professions."--from the introduction In the widely acclaimed Higher Superstition: The Academic Left and Its Quarrels with Science, Paul R. (...) Gross and Norman Levitt offered a spirited response to the "science bashers," raising serious questions about the growing criticism of scientific practice from humanists and social scientists on the academic left. Now, in The Flight from Science and Reason, Gross and Levitt are joined by Martin W. Lewis to bring together a diverse and distinguished group of scholars, scientists, and experts to engage these questions from a wide variety of perspectives. The authors take on critics of science whose views range from moderate to extreme, from social constructivists to deconstructionists, from creationists and feminists to Afro-centrists. They discuss the rise of "alternative medicine" and radical environmentalism (here skewered as "ecosentimentalism"). They explain why the "uncertainty principle" does not work as a metaphor for ambiguity, and why "chaos theory" cannot be invoked without an understanding of mathematics. Throughout, they grapple with the paradox inherent in arguing with opponents who contend that reason itself, and thus logic, is suspect. Distributed for the New York Academy of Sciences. (shrink)

The U.S. Food and Drug Administration's rationale for supporting the development and approval of BiDil for heart failure specifically in black patients was based on under-powered, post hoc subgroup analyses of two relatively old trials , which were further complicated by substantial covariate imbalances between racial groups. Indeed, the only statistically significant difference observed between black and white patients was found without any adjustment for potential confounders in samples that were unlikely to have been adequately randomized. Meanwhile, because the accepted (...) baseline therapy for heart failure has substantially improved since these trials took place, their results cannot be combined with data from the more recent trial amongst black patients alone. There is therefore little scientific evidence to support the approval of BiDil only for use in black patients, and the FDA's rationale fails to consider the ethical consequences of recognizing racial categories as valid markers of innate biological difference, and permitting the development of group-specific therapies that are subject to commercial incentives rather than scientific evidence or therapeutic imperatives. This paper reviews the limitations in the scientific evidence used to support the approval of BiDil only for use in black patients; calls for further analysis of the V-HeFT I and II data which might clarify whether responses to H-I vary by race; and evaluates the consequences of commercial incentives to develop racialized medicines. We recommend that the FDA revise the procedures they use to examine applications for race-based therapies to ensure that these are based on robust scientific claims and do not undermine the aims of the 1992 Revitalization Act. (shrink)

BackgroundInaccurate citations are erroneous quotations or instances of paraphrasing of previously published material that mislead readers about the claims of the cited source. They are often unaddressed due to underreporting, the inability of peer reviewers and editors to detect them, and editors’ reluctance to publish corrections about them. In this paper, we propose a new tool that could be used to tackle their circulation.MethodsWe provide a review of available data about inaccurate citations and analytically explore current ways of reporting and (...) dealing with these inaccuracies. Consequently, we make a distinction between publication and circulation of inaccurate citations. Sloppy reading of published items, literature ambiguity and insufficient quality control in the editorial process are identified as factors that contribute to the publication of inaccurate citations. However, reiteration or copy-pasting without checking the validity of citations, paralleled with lack of resources/motivation to report/correct inaccurate citations contribute to their circulation.Results and discussionWe propose the development of an online annotation tool called “MyCites” as means with which to mark and map inaccurate citations. This tool allows ORCID users to annotate citations and alert authors and also editors of journals where inaccurate citations are published. Each marked citation would travel with the digital version of the document and be visible on websites that host peer-reviewed articles. In the future development of MyCites, challenges such as the conditions of correct/incorrect-ness and parties that should adjudicate that, and, the issue of dealing with incorrect reports need to be addressed. (shrink)

In this short think-piece we trace the newly emerging and rapidly expanding dimensions and dynamics of the “neuro-complex.” What this amounts to, we suggest, are a series of bio or neuro “convergences” of sorts regarding the brain and mental worlds, which in turn are traceable through what we term the bio-psych, pharma-psych, subjectivity-selves, wellness-enhancement, and the neuroculture-neurofutures relational nexuses. These issues are then illustrated through two brief case studies regarding brain scanning technologies and the problems and prospects of cognitive enhancement. (...) The paper concludes with some final reflections on these matters and a call for further research in this rich and challenging domain as the neuro-complex continues to expand in expected and unexpected, yet equally rich and fascinating, ways. (shrink)

In this paper we discuss Brandom's definition of necessity, which is part of the incompatibility sematnics he develops in his fifth John Locke Lecture. By comparing incompatibility semantics to standard Kripkean possible worlds semantics for modality, we motivate an alternative definition of necessity in Brandom's own terms. Our investigation of this alternative necessity will show that - contra to Brandom's own results - incompatibility semantics does not necessarily lead to the notion of necessity of the modal logic S5.

An electronic poster from "Polarity from Different Perspectives," New York University, 2005. The authors present an experiment that investigated to what extent six negative polarity items (slept a wink, in ages, ever, much, at all, and yet) are licensed by 9 potential licensers.

Ibn Rushd (1126-1198), or Averroes, is widely known as the unrivalled commentator on virtually all works by Aristotle. His commentaries and treatises were used as manuals for understanding Aristotelian philosophy until the Age of the Enlightenment. Both Averroes and the movement commonly known as 'Latin Averroism' have attracted considerable attention from historians of philosophy and science. Whereas most studies focus on Averroes' psychology, particularly on his doctrine of the 'unity of the intellect', Averroes' natural philosophy as a whole and its (...) influence still remain largely unexplored. This volume aims to fill the gap by studying various aspects of Averroes' natural philosophical thought, in order to evaluate its impact on the history of philosophy and science between the late Middle Ages and the Early Modern Period. (shrink)

We discuss Kant’s conception of beneficence against the background of the overdemandingness debate. We argue that Kant’s conception of beneficence constitutes a sweet spot between overdemandingess and undemandingess. To this end we defend four key claims that together constitute a novel interpretation of Kant’s account of beneficence: 1) for the same reason that we are obligated to be beneficent to others we are permitted to be beneficent to ourselves; 2) we can prioritise our own ends; 3) it is more virtuous (...) to do more rather than less when it comes to helping others; and 4) indifference to others is vicious. Finally, we explain how this represents a system of duties that gives our personal ends a moral standing without unacceptably moralising them. (shrink)

Thinking Radical Democracy is an introduction to nine key political thinkers who contributed to the emergence of radical democratic thought in post-war French political theory: Hannah Arendt, Maurice Merleau-Ponty, Pierre Clastres, Claude Lefort, Cornelius Castoriadis, Guy Debord, Jacques Rancière, Étienne Balibar, and Miguel Abensour. The essays in this collection connect these writers through their shared contribution to the idea that division and difference in politics can be perceived as productive, creative, and fundamentally democratic. The questions they raise regarding equality and (...) emancipation in a democratic society will be of interest to those studying social and political thought or democratic activist movements like the Occupy movements and Idle No More. --Provided by publisher. (shrink)

Music is a natural human expression present in all cultures, but the functions it serves are still debated. Previous research indicates that rhythm, an essential feature of music, can enhance coordination of movement and increase social bonding. However, the prolonged effects of rhythm have not yet been investigated. In this study, pairs of participants were exposed to one of three kinds of auditory stimuli (rhythmic, arrhythmic, or white‐noise) and subsequently engaged in five trials of a joint‐action task demanding interpersonal coordination. (...) We show that when compared with the other two stimuli, exposure to the rhythmic beat reduced the practice effect in task performance. Analysis of the behavioral data suggests that this reduction results from more temporally coupled motor movements over successive trials and that shared exposure to rhythm facilitates interpersonal motor coupling, which in this context serves to impede the attainment of necessary dynamic coordination. We propose that rhythm has the potential to enhance interpersonal motor coupling, which might serve as a mechanism behind its facilitation of positive social attitudes. (shrink)

This edition of Giovanni Pico della Mirandola’s “De ente et uno” (“On being and the one”) offers for the first time a key text for the reformation of metaphysics in Renaissance philosophy in German translation. The Latin text is added. The detailed introduction and careful commentary reveal the guiding points Pico has set with this work.